Stripes in red and organization of my library

Hello, I’m using Engine DJ together with a Standalone Denon Prime 4 and I have a question, suppose I’ve done all the organization of my library from Serato Dj and the storage is an EXTERNAL SSD, after organizing this library and doing the backup inside the Engine DJ, if I want to format the External SSD or modify the folders, will it interfere with my organization in the internal storage of the Prime 4 in the next synchronization?