Can prime 4 play to Bluetooth jbl speakers or through Heos?

I doubt it would work for anything that requires real-time audio manipulation. In DJ cases mixing, cueing, etx.

The only way to get to wirelessly connecting (serious) speakers (i.e. not BT), MIGHT be by using something like these (expensive) Neutrik wireless XLR systems:

https://www.neutrik.com/en/neutrik/products/xirium-pro/xirium-pro-europe