My honest opinion, you need to buy a SATA drive SSD of reasonable quality (see the other thread relating to hard drive issues) and install it inside the device, then use that.
The data transfer and read speeds of SATA far outweigh anything a USB port can do.
I have a Western Digital blue installed on my Prime 2, exporting my music collection to it is rapid and so is search my library.
I just found this, it looks like the ports on the top only support USB 2.0 so it’s going to bottleneck at that speed. You can plug it in the back for 3.0 but even then with that library you should really think about a SATA SSD installed in the device, it’s a game changer.